Dr. Curtis Connors was once a genetic biologist and mentor to Peter Parker. He sought a way to use reptilian DNA to regenerate lost limbs, such as his own lost arm. After testing his experimental serum on himself, Connors transformed into the inhuman reptilian creature, Lizard.
Sergei Kravinoff is Kraven the Hunter, a fanatical big game hunter who seeks to claim Spider-Man as a prize to prove that he is the best hunter in the world. From the hidden jungles of the Savage Land to the cityscape of New York City, Kraven won't relent until he's claimed his trophy.
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