Nathaniel Essex was once a biologist in Victorian London. Realizing that an increasing number of human mutations marked the beginning of a new evolution, Essex set aside morality in his quest to perfect the human race. A long path of unethical experiments on unwilling subjects eventually led to incredible discoveries and even greater personal power. Nathaniel became much more than human and transformed into the near-immortal being known as Mister Sinister. Mister Sinister sees the mutant race's eventual dominance over the world as a foregone conclusion, and that we must now look beyond the next step. Believing that certain genetic lineages possess greater mutant power than others, Mister Sinister has targeted members of the X-Men as possible experimental subjects. Regardless of the opposition, Mister Sinister will let nothing impede his quest for evolutionary perfection.
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